Titlebook: Mammalian Transient Receptor Potential (TRP) Cation Channels; Volume II Bernd Nilius,Veit Flockerzi Book 2014 Springer International Publis

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TRP Channels and Thermosensationor heating. Based on this characteristic feature, these so-called “thermoTRPs” have been widely studied with the aim to elucidate their potential key role as thermosensors in the somatosensory system and to understand the basis of their high thermal sensitivity. In this chapter, I provide a brief cr

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TRPs as Chemosensors (ROS, RNS, RCS, Gasotransmitters) from outside and inside the cell. Upon chemical or physical stimulation of cells, TRP channels transduce electrical and/or Ca. signals via their cation channel activities. These functional features of TRP channels allow the body to react and adapt to different forms of environmental changes. Indeed

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TRPs in Taste and Chemesthesisemical stimuli, giving rise to sensations of taste, irritation, warmth, coolness, and pungency. Specifically, TRPM5 acts downstream of taste receptors in the taste transduction pathway. TRPM5 channels convert taste-evoked intracellular Ca. release into membrane depolarization to trigger taste transm

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TRPs and Pain and can become chronic and debilitating. A demand for more effective treatments to deal with this highly prevalent problem requires a better understanding of the underlying mechanisms. TRP channels are associated with numerous sensory functions across a wide range of species. Investigation into the

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TRPs in Hearingceed Brownian motion. Attempts to molecularly identify these auditory transduction channels have put the focus on TRPs in ears. In ., hearing has been shown to involve TRPA, TRPC, TRPN, and TRPV subfamily members, with candidate auditory transduction channels including NOMPC (=TRPN1) and the TRPVs N

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Extort

Structural Biology of TRP Channelsre determination. We review recent progress towards a structural understanding of TRP channels and the techniques used to that end. We discuss available low-resolution structures from electron microscopy (EM), X-ray crystallography, and nuclear magnetic resonance (NMR) and review the resulting insig