Titlebook: Mammalian Transient Receptor Potential (TRP) Cation Channels; Volume II Bernd Nilius,Veit Flockerzi Book 2014 Springer International Publis

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Photosensitive TRPsG protein-coupled phospholipase C (PLCβ4) cascade. Although still debated, recent evidence indicates the channels can be activated by a combination of PIP. depletion and protons released by the PLC reaction. PIP. depletion may act mechanically as membrane area is reduced by cleavage of PIP.’s bulky

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TRPs in Taste and Chemesthesis In many sensory fibers and epithelial cells lining the oronasal cavity, TRPA1 is also co-expressed with TRPV1. As with TRPV1, TRPA1 transduces a wide variety of irritants and, in combination with TRPV1, assures that there is a broad response to noxious chemical stimuli. Other TRP channels, includin

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TRPs in Olfactiontory system but that other TRP channel subtypes such as TRPC1, TRPC4, TRPC6, TRPM4, and TRPM5 could also play important functional roles in mammalian olfaction. Here, I review such findings and discuss future areas for investigation.

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The TRPCs–STIM1–Orai Interactionific and non-overlapping physiological functions of Ca. influx mediated by the two channel types, and argue that the TRPC channels should be the preferred therapeutic target to control the toxic effect of excess Ca. influx.

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The TRPC Family of TRP Channels: Roles Inferred (Mostly) from Knockout Mice and Relationship to ORAI containing channels, a plethora of studies have shown TRPCs to be important both in physiologic systems as well as in pathophysiologic phenomena. Particularly important in defining roles of TRPCs, have been studies with mice with targeted disruption of their genes, i.e., with TRPC KO mice. In this

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TRPs: Modulation by Drug-Like Compounds only underwent a preliminary validation. For some TRP channels, reliable low molecular weight inhibitors are not yet available. Hence, further efforts need to be undertaken in order to explore the physiological impact and possible therapeutic potential of TRP channel targeting with drug-like compou

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TRP Modulation by Natural Compoundsn order to find new drug classes to treat different disorders. Indeed, the transient receptor potential (TRP) proteins are targets for several natural compounds, and antagonists of TRPs have been synthesised based on the knowledge of naturally derived products. In this context, this chapter focuses

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