Titlebook: Malaria: Drugs, Disease and Post-genomic Biology; R. W. Compans,M. D. Cooper,Sanjeev Krishna Book 2005 The Editor(s) (if applicable) and T

radionuclides

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厚脸皮

A Post-genomic View of the Mitochondrion in Malaria Parasitesogy in this post-genomic era. Although in many cases direct experimental proof for their mitochondrial functionsmay not be available at present, descriptions of these potential mitochondrial proteins can provide a basis for experimental approaches.

eustachian-tube

Plasmodium Permeomics: Membrane Transport Proteins in the Malaria Parasiteparticular physiological measurements on the parasite and parasitized erythrocyte, the annotation of transport proteins in the . genome, and molecular methods used to analyze transport protein function.

Highbrow

Functional Proteome and Expression Analysis of Sporozoites and Hepatic Stages of Malaria Developmentis critical to identify novel pre-erythrocytic drug and vaccine targets as well as to understand the basic biology of this deadly parasite. Both transcriptional and proteomic analyses on these stages and the remaining stages of development will assist in the ‘credentialing process’ of the complete malaria genome.

vector

Hemoglobin Degradationo be exploited for development of antimalarial agents that will starve the parasite or result in build-up of toxic intermediates. There are a number of unanswered questions concerning the cell biology, biochemistry and metabolic roles of this crucial pathway.

流利圆滑

Ookinete Invasion of the Mosquito Midgutill consider basic aspects of ookinete biology, molecules known to be involved in midgut invasion, and cellular processes of the ookinete that facilitate parasite invasion. Detailed knowledge of these mechanisms may be exploitable in the future towards developing novel strategies of blocking malaria transmission.

去才蔑视

0070-217X uses symptomatic disease in a further 300 million individuals. This volume brings some of the world‘s best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two.978-3-642-06471-5978-3-540-29088-9Series ISSN 0070-217X Series E-IS

Apraxia

Quinolines and Artemisinin: Chemistry, Biology and Historyect of the quinolines and artemisinins, great progress has been made recently in studying the mechanisms of drug action and drug resistance in malaria parasites. Here we summarize from a historical, biological and chemical, perspective the exciting new advances that have been made in the study of these important antimalarial drugs.

Glaci冰