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Titlebook: Major Sex-Determining Genes; Susumu Ohno Book 1979 Springer-Verlag Berlin · Heidelberg 1979 animals.genes.sex

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Initial Gonadal Differentiation and the History of H-Y Antigenalian Y chromosome directs testicular organization by specifying a male-specific plasma membrane component or components that have been conserved in evolution. Before we proceed any further, however, an outstanding peculiarity of testicular organogenesis should be noted.
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Testis-Organizing Function of H-Y Antigenle of the H-Y antigent almost had to be that of the primary (gonadal) sex determiner. H-Y antigen must have been diverting the emerging gonad’s inherent tendency to develop into an ovary, causing it to organize a testis instead.
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Why Are a Number of Unlinked Genes Involved in H-Y Antigen Expression ? form of genetic regulatory system, however, is likely to operate at the periphery of a given regulatory hierarchy. Organogenesis being one of the earlier events of ontogeny, the role of organogenesis-directing antigen is to trigger the sequential activation of subsidiary regulatory systems, some of which may form feedback loops.
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Why Sexual Dimorphism?ished with considerable expense) contains a like-sexed pair. During the past few years, I have occasionally been consulted to determine the sex of individual eagles either by sex chromosome analysis or by H-Y antigen typing.
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Abolition of All Adrogen Target Organ Responses by the X-Linked Tfm (Testicular Feminization) Mutatiause no sexual difference in the responsiveness to androgens has been noted either during the critical fetal stage or during the postpubertal stage, the above-noted molecule must be present in males and females alike. Thus, we realize that the two regulatory hierarchies are completely separated from and independent of each other.
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Book 1979im in the epic battle just concluded. Because Epimetheus, who had been endowed only with hindsight, had the first hand in this creation, all the good attributes were exhaus­ ted by the time the lion, the elephant and other animals were created. When the time came for the creation of man, there were
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