Titlebook: Macromolecular Protein Complexes III: Structure and Function; J. Robin Harris,Jon Marles-Wright Book 2021 Springer Nature Switzerland AG 2

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Structure, Dynamics and Function of the 26S Proteasome, visualization of the 26S proteasome dynamics during polyubiquitylated substrate degradation elucidated an extensively detailed picture of its functional mechanisms, owing to progressive methodological advances associated with cryogenic electron microscopy (cryo-EM). Multiple sites of ubiquitin bind

Counteract

Judicious

Structure and Function of the Separase-Securin Complex, the separase-securin complex have revealed the molecular mechanism for the inhibitory activity of securin. A segment of securin is bound in the active site of separase, thereby blocking substrate binding. Securin itself is not cleaved by separase as its binding mode is not compatible with catalysis

Cytology

Architecture and Assembly of the Bacterial Flagellar Motor Complex,lizes efficient chemotaxis while performing high-speed movement by an ingenious directional switching mechanism of the motor rotation. To build the universal joint and helical propeller structures outside the cell body, the flagellar motor contains its own protein transporter called a type III prote

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Cellulosomes: Highly Efficient Cellulolytic Complexes,ven though cellulosome producing organisms are relatively few, the development of new genomic and proteomic technologies has allowed the identification of cellulosomal components in many archea, bacteria and even some primitive eukaryotes. This reflects the importance of this cellulolytic strategy a

ALIAS

buoyant

The SF3b Complex is an Integral Component of the Spliceosome and Targeted by Natural Product-Based be drivers of disease. Finally, the SF3b complex is the target for at least three different classes of natural product-based inhibitors. These inhibitors bind in the BP adenosine-binding pocket and demonstrate a pre-mRNA competitive mechanism of action resulting in either intron retention or exon s

Ingenuity

infinite

agglomerate

Fibrinogen and Fibrin,nd whole clot levels and are among the most important functional characteristics, enabling the blood clot to withstand arterial blood flow, platelet-driven clot contraction, and other dynamic forces. This chapter describes the molecular structure of fibrinogen, the conversion of fibrinogen to fibrin