| 书目名称 | Macro Roles for MicroRNAs in the Life and Death of Neurons |
| 编辑 | Bart De Strooper,Yves Christen |
| 视频video | |
| 概述 | Includes supplementary material: |
| 丛书名称 | Research and Perspectives in Neurosciences |
| 图书封面 |  |
| 描述 | .The discovery of microRNAs has revealed an unexpected and spectacular additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. Since the initial studies performed in C.elegans, we have gone a far way to begin to understand how microRNA pathways can have an impact on health and disease in human. Although microRNAs are abundantly expressed in the brain, relatively little is known about the multiple functions of these RNA molecules in the nervous system. Nevertheless, we know already that microRNA pathways play major roles in the proliferation, differentiation, function and maintenance of neuronal cells. Several intriguing studies have linked microRNAs as major regulators of the neuronal phenotype, and have implicated specific microRNAs in the regulation of synapse formation and plasticity. Dysfunction of microRNA pathways is also slowly emerging as a potential important contributor to the pathogenesis of major neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. These novel insights appear to be particular promising for the understanding |
| 出版日期 | Book 2010 |
| 关键词 | Alzheimer; Alzheimer‘s disease; Nervous System; Parkinson; Parkinson‘s disease; genes; genetics; microRNA p |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-04298-0 |
| isbn_softcover | 978-3-642-26204-3 |
| isbn_ebook | 978-3-642-04298-0Series ISSN 0945-6082 Series E-ISSN 2196-3096 |
| issn_series | 0945-6082 |
| copyright | Springer-Verlag Berlin Heidelberg 2010 |
发表于 2025-3-21 16:40:53
