| 书目名称 | MACPF/CDC Proteins - Agents of Defence, Attack and Invasion | | 编辑 | Gregor Anderluh,Robert Gilbert | | 视频video | | | 概述 | A comprehensive overview of one of the largest pore forming proteins superfamilies.A special chapter on methodology allowing the study of mechanisms of pore formation.Several novel data reviews which | | 丛书名称 | Subcellular Biochemistry | | 图书封面 |  | | 描述 | .This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein super family that was originally discovered because of unexpected structural similarity between a domain present in bacterial cholesterol-dependent cytolysins (CDC) and proteins of the membrane attack complex/perforin (MACPF) family. Members of the MACPF/CDC super family are crucial for many biological processes, being efficient agents of development, defence, attack and invasion of cells and tissues. However, their best-known role is in bacterial pathogenesis and the proper functioning of the vertebrate immune system, via formation of transmembrane pores in target cell membranes..The book contains chapters on the distribution of MACPF/CDC proteins and on aspects of their evolution and structural properties, the similarities between different super family members and functional properties of some of the best known examples. The book also contains an overview of biophysical approaches that may be used in the future to provide further i | | 出版日期 | Book 2014 | | 关键词 | MACPF/CDC superfamily; bacterial pathogenesis; biophysical approaches; immunity; pore forming proteins; E | | 版次 | 1 | | doi | https://doi.org/10.1007/978-94-017-8881-6 | | isbn_softcover | 978-94-024-0339-8 | | isbn_ebook | 978-94-017-8881-6Series ISSN 0306-0225 Series E-ISSN 2542-8810 | | issn_series | 0306-0225 | | copyright | Springer Science+Business Media Dordrecht 2014 |
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发表于 2025-3-21 17:18:52
