Titlebook: Lymphocytes, Macrophages, and Cancer; Georges Mathé,Irène Florentin,Marie-Christine Simm Book 1976 Springer-Verlag Berlin · Heidelberg 197

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Liposomes as Immunological Adjuvants,es and then on helper T-lymphocytes; for these the term T-adjuvants has been proposed. However, some adjuvants, such as bacterial lipopolysaccharide, appear to be able to stimulate B-lymphocytes directly without the agency of T-lympho-cytes; these can be termed B-adjuvants.

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Book 1976xic for tumor cells in vitro. This cytotoxic activity w~s already maximal 14 days after injection of 1 mg of BCG and remained stable when 3 or 5 mg of BCG were given. At the same time spleen cells of the BCG-treat~d mice showed strongly depressed responses to the T-cell mitogens,PHA and Con A, irres

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In vitro Interactions Between Tumor Cells and Immune Lymphoid Cells,s it is useful to return to clear experimental models to try to etablish the significance of the in vitro methods used in investigations on cell-mediated antitumor immunity, and to determine whether the anti-tumor immune response is actually a response against the tumor or in fact an intercurrent phenomenon.

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An Immunological Classification of Leukemias and Hematosarcomas Based on Cell Membrane Markers withThe identification, several years ago, of membrane markers on the mononuclear cell population of both animals (.) and humans (., ., ., ., ., ., ., .) has permitted differentiation of this population into T- (thymodependent) and B- (thymoindependent) lymphocytes and a third cell category including monocytes (., .).

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,Increase in “Null” Cells in Acute Lymphocytic Leukemia in Remission on Long-Term Immunotherapy,these publications have recently appeared (., .). Although experimental evidence regarding the mechanism of action of BCG and/or inactivated tumor cells on animal immune systems is abundant (., ., ., ., .), consistent data in humans is still scanty.

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