Titlebook: Long Noncoding RNAs; Structures and Funct Riki Kurokawa Book 2015 Springer Japan 2015 Bioinformatics.Chemical biology.Epigenetics.Macrophag

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Complexity of Mammalian Transcriptome Analyzed by RNA Deep Sequencing genome was considered silent and non-functional, until on-going research revealed that about 80 % of DNA might be transcribed, producing numerous long noncoding RNA molecules with important functions. This chapter gives an overview of mammalian transcriptome research in recent decades. It discusses

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Synthetic Strategies to Identify and Regulate Noncoding RNAsble researchers to develop novel therapeutic strategies and would aid the elucidation of the intricate translational machinery. In this chapter, we give a chemical perspective of ncRNAs and detail the synthetic strategies available to modulate novel RNA structures, which have been identified as ther

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Structure and Interaction with Protein of Noncoding RNA: A Case for an RNA Aptamer Against Prion Proased assay demonstrated that R12 reduces the amount of the abnormal form of prion protein and thus exerts anti-prion activity. The R12 aptamer may be utilized to develop drugs against prion diseases and Alzheimer’s disease.

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Characterization of G-Quadruplex DNA- and RNA-Binding Proteinitution of Tyr for Phe in the RGG motif of TLS converts its binding specificity solely toward G-quadruplex TERRA. This molecule binds to loops within the G-quadruplexes of TERRA by recognizing the 2′-OH of the riboses. It will be useful for investigating biological roles of the G-quadruplex in long

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Long Noncoding RNAs as Structural and Functional Components of Nuclear Bodiesanscriptional and post-transcriptional regulation of genes by modulating the function and localization of related regulatory proteins. In this review, we focus on the recently unveiled roles of lncRNAs that act as structural and/or functional components of nuclear bodies.

Stable-Angina

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Mechanisms of Long Noncoding Xist RNA-Mediated Chromosome-Wide Gene Silencing in X-Chromosome InactiXist RNA-mediated chromosome-wide silencing and particularly the Xist RNA domains and protein factors essential for Xist RNA localization on the Xi. In this chapter, we describe recent novel findings in X-inactivation with a special focus on how Xist RNA localizes on the Xi . and recruits various ch

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