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Titlebook: Liver Metastasis: Biology and Clinical Management; Pnina Brodt Book 2011 Springer Science+Business Media B.V. 2011 Breast cancer.Cancer an

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书目名称Liver Metastasis: Biology and Clinical Management
编辑Pnina Brodt
视频video
概述Comprehensive and timely reviews on different aspects of the Biology of liver metastasis.A unique combination of chapters on basic biological mechanisms and clinical aspects of liver metastasis writte
丛书名称Cancer Metastasis - Biology and Treatment
图书封面Titlebook: Liver Metastasis: Biology and Clinical Management;  Pnina Brodt Book 2011 Springer Science+Business Media B.V. 2011 Breast cancer.Cancer an
描述.Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential.  . .Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails.   Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews
出版日期Book 2011
关键词Breast cancer; Cancer and Inflammation; Colon cancer; Liver metastasis; Liver microenvironment; surgical
版次1
doihttps://doi.org/10.1007/978-94-007-0292-9
isbn_softcover978-94-007-3545-3
isbn_ebook978-94-007-0292-9Series ISSN 1568-2102 Series E-ISSN 2215-1648
issn_series 1568-2102
copyrightSpringer Science+Business Media B.V. 2011
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Introduction,ch as colorectal (CRC), neuroendocrine, pancreatic, esophageal and gastric carcinomas. For CRC, over 50% of patients will present with liver metastases either at the time of diagnosis or after resection of the primary tumor [1].
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The Tumor Microenvironment at Different Stages of Hepatic Metastasisduring the process of hepatic metastasis. To this end, four consecutive phases in the process, each with distinct mechanisms, have been considered: (1) The microvascular phase of liver-infiltrating cancer cells that includes mechanisms of intravascular arrest, death or survival of cancer cells at sp
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