| 书目名称 | Liver Intra-arterial PRRT with 111In-Octreotide | | 副标题 | The Tumoricidal Effi | | 编辑 | Georgios S. Limouris | | 视频video | | | 概述 | Highlights the efficacy of Auger and Internal Conversion Electron irradiation as a potent tumoricidal tool..Demonstrates the intra-arterial radionuclide infusion technique’s superiority over intraveno | | 图书封面 |  | | 描述 | .This book describes in detail a clinical project that reveals the tumoricidal efficacy of Auger and internal conversion electrons, emitted from n.c.a. .111.In and implemented in oncology as a treating armamentarium for peptide receptor radionuclide therapy (PRRT), targeting small size (ø ≤ 20 mm) tumors and micro-metastases..The keen interest in n.c.a. .111.In began when it was observed that its Auger electron emission could be highly radiotoxic, due to its high LET when it decayed in the vicinity of cellular DNA. The somatostatin analog octreotide, labeled with [.111.In-diethylenetriaminepentaacetic acid (DTPA.0.-D-Phe.1.)] is an established diagnostic agent for the imaging of somatostatin receptor-positive neuro- (or non-neuro) endocrine tumors. It relies on receptor-mediated binding, internalization and installation in the lysosomes in the proximity of the nucleus; administered in large doses, loco-regionally, via the feeding artery of solid tumors, can be highly radiotoxic if they over-express somatostatin receptors, mainly of the sst2 histotype..The book compares the results between i.v. and i.a. implementation in more than 80 patients after over 800 i.a. infusions in neuroen | | 出版日期 | Book 2021 | | 关键词 | Neuroendocrine; Tumor; Radionuclide treatment; Octreoscan; Electron emissions | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-70773-6 | | isbn_softcover | 978-3-030-70775-0 | | isbn_ebook | 978-3-030-70773-6 | | copyright | Springer Nature Switzerland AG 2021 |
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发表于 2025-3-21 17:40:59
