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Titlebook: Liver Growth and Repair; Alastair Strain,Anne Mae Diehl Book 1998 Springer Science+Business Media Dordrecht 1998 cells.cyclin.development.

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书目名称Liver Growth and Repair
编辑Alastair Strain,Anne Mae Diehl
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图书封面Titlebook: Liver Growth and Repair;  Alastair Strain,Anne Mae Diehl Book 1998 Springer Science+Business Media Dordrecht 1998 cells.cyclin.development.
描述Nelson Fausto The Greek myth of Prometheus with its picture of a vulture feasting on its chained victimhas traditionallyprovided a visualimageofliverregeneration. Itis apowerful and frightening representationbut ifone were to substitute the vulture by a surgeon and Prometheus by a patient laying on a properly prepared operating table, the outcomeoftheprocedurewould not differ significantlyfrom that describedbyGreek poets. Yet few of us who work in the field have stopped long enough to ask where this myth originated. Did the poet observe a case of liver regeneration in a human being? Was it brilliant intuition or perhaps, literally, just a ‘gut feeling‘ of a poet looking for good rhymes that led to the prediction that livers grow when part of the tissueisremoved? Thisbookdoesnotattemptto solve these historical issues. Itdoes, instead, cover in detail some of the major modem themes of research on liver regen­ eration, injury and repair. As indicated in Dr. N. Bucher‘s chapter, the modem phase ofexperimental studies on liver regeneration started in 1931 with the publication by Higgins and Anderson of a method to perform a two-thirds resection of the liver of a rat. The technique descr
出版日期Book 1998
关键词cells; cyclin; development; endothelium; genes; transcription
版次1
doihttps://doi.org/10.1007/978-94-011-4932-7
isbn_softcover978-94-010-6069-1
isbn_ebook978-94-011-4932-7
copyrightSpringer Science+Business Media Dordrecht 1998
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978-94-010-6069-1Springer Science+Business Media Dordrecht 1998
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Proto-oncogenes/ transcription factors of these events are presumably intimately linked with the eventual regeneration of the liver, whereas others are likely to be stress-related or required for the continued differentiated function of the liver while regeneration is occurring.
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Proteoglycansll-matrix and cell-cell adhesion, control of extracellular enzymic activities and the regulation of cell growth itself, through modulation of growth factor activation (for reviews see Gallagher, 1989; Couchman and Woods, 1993).
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in vivoRecent molecular biology has enabled remarkable progress in biological research. However, this biological achievement requires evaluation by different approaches, particularly in the understanding of complexity in dynamic organs. Such a situation exists exactly in the regulatory mechanisms of liver regeneration.
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CytokinesLiver growth occurring after liver damage or partial hepatectomy is a well-known phenomenon in the wide field of hepatology. While liver repair may involve repair mechanisms also observed in other organs, it is characteristic of the liver to generate the previous organ mass after partial hepatectomy in a very short time.
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Liver regeneration following hepatic injuryd hepatocellular proliferation in the . model of partial hepatectomy. In contrast, the characteristics and mechanisms of hepatic regeneration stimulated by liver cell loss from hepatocyte injury and cell death rather than surgical resection are largely unknown. The reasons for this imbalance in our
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Epithelial stem-like cells of the rodent liverence that has accumulated from nearly 100 years of investigation into the biology of the liver. Early in this century, investigators recognized potential lineage relationships among biliary epithelial cells, transitional cells and hepatocytes in several rodent models of liver regeneration (MacCallum
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