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Titlebook: Liver Carcinogenesis; The Molecular Pathwa George G. Skouteris Conference proceedings 1994 Springer-Verlag Berlin Heidelberg 1994 Cancer Re

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HGF and Liver Growth Regulation,n in rats as shown by Higgins and Anderson (1931) led to a definition of phenomena related to liver regeneration which were well reproduced and became the guiding lines for research in the years that followed.
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Conference proceedings 1994HGF functions as a pleotropic factor in the liver as well as in other extrahepatic tissues. The hepatic stem cell compartment is thought to play a major role in liver tissue restoration. Mechanisms of cell growth and cell death of the liver are described in detail, with particular emphasis on apopto
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Hepatocyte Growth Factor and Its Variant with a Deletion of Five Amino Acids are Distinguishable ingen for hepatocytes, it also stimulates the growth of various epithelial and endothelial cells (Rubin et al., 1991); it inhibits the growth of tumor cells (Higashio et al., 1990; Shima et al., 1991a); and it stimulates the mobility of epithelial (Gherardi et al., 1989) and endothelial cells (Rosen et al., 1990).
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Hepatic Recovery of Dimethylnitrosamine-Cirrhotic Rats after Injection of the Liver Growth Factor,the most frequent, and many authors have proposed it as the step immediately preceding the appearance of HCC (Johnson and Williams, 1987). For this reason, any significant advance in the treatment of cirrhosis ought to have a clear impact in diminishing HCC incidence.
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