Titlebook: Liver Cancers; From Mechanisms to M Tim Cross,Daniel H. Palmer Book 2019 Springer Nature Switzerland AG 2019 Hepatocellular Carcinoma.Chola

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The Epidemiology of Hepatocellular Carcinomarapidly and becoming a major public health problem. In the Far East and sub-Saharan Africa, the cancer is common and invariably fatal so that overall, HCC is the second most common cause of cancer-related death. The major risk factor is chronic hepatitis B virus (HBV) infection, particularly in the

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Mechanisms of Disease: The Damaged Genome in HCCapies. Enormous recent progress has been made in trying to understand the complexity of the altered genome in this cancer and the potential this holds for designing the diagnostics and treatments of the future. In this review we summarise recent data investigating the genetic predisposition to HCC d

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Diagnosis and Staging of Hepatocellular Carcinoma (HCC)erent nodules to contrast injection and diffusion weighting. In those with indeterminate nodules on imaging criteria or with non-cirrhotic livers, a tissue diagnosis (biopsy) is needed to establish the diagnosis. Once diagnosed there are several staging systems, for both the cancer and underlying li

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Liver Transplantation for the Treatment of Hepatocellular Carcinomae HCC can be treated by liver transplantation with excellent outcomes, whereas advanced HCC has a poor prognosis. Criteria based on size and number of HCC are commonly used to identify patients likely to benefit from liver transplantation; however, even in highly selected patients HCC recurrence may

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The Role of Interventional Radiology and Image-Guided Ablation in Primary Liver Cancerns the definitive treatment, a lack of donors worldwide excludes this treatment as a realistic possibility for most sufferers. Surgical resection provides the opportunity for cure; however, stringent patient selection criteria employed to avoid complications often means many patients are not eligibl

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