Titlebook: Liver Cancer; Joseph C. Bottino,Richard W. Opfell,Franco M. Mugg Book 1985 Martinus Nijhoff Publishing, Boston 1985 adjuvant therapy.liver

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Chemotherapy of Liver Canceratment; regional infusion chemotherapy; combination or multidrug chemotherapy; and finally, the present resurgence of regional delivery systems with single or multiple agents. The chemotherapeutic agents employed as a common denominator throughout the chronology of liver tumor therapy have been the

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New Chemotherapeutic Agents in Liver Canceruse of investigational approaches including resection, embolization, intra-arterial cytotoxic therapy, radiation, and a combination of these, as well as the trial of new and standard drugs or combination regimens by the systemic route. Pharmacologic studies are becoming more frequent and are essenti

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Pharmacologic Studies of Hepatic Intra-Arterial Chemotherapyic effect [1]. Even when systemically administered (intravenous) chemotherapy is relatively ineffective, intra-arterial chemotherapy may still improve the likelihood of response by the generation of much greater drug exposures (defined by the concentration × time integral). Hepatic arterial chemothe

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Regional Chemotherapy of Liver Cancerver metastases are found at autopsy in 41–75% of patients dying of cancer [2 and table 14–1]. Surgery offers the only possibility of cure [chapter 7]; but resection is possible in only 10–20% of primary and 5% of secondary liver cancers. Systemic chemotherapy has not consistently produced responses

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Regional Arterial Therapy in the Management of Primary Liver Neoplasmsarterial chemotherapeutic agents had very little effect upon the survival of these patients despite tumor shrinkage [3,4]. An early report with doxorubicin, given intravenously as a single agent or in combination with other drugs, resulted in a response of 78% [5]. Later studies reported response ra

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Joseph C. Bottino,Richard W. Opfell,Franco M. Mugg

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Chusilp Charnsangavej,Sidney Wallace,C. Humberto Carrasco,William Bechtel

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