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Titlebook: Lipoproteins and Atherosclerosis; C. L. Malmendier,P. Alaupovic Book 1987 The Editor(s) (if applicable) and The Author(s), under exclusive

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发表于 2025-3-21 17:23:45 | 显示全部楼层 |阅读模式
书目名称Lipoproteins and Atherosclerosis
编辑C. L. Malmendier,P. Alaupovic
视频video
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Lipoproteins and Atherosclerosis;  C. L. Malmendier,P. Alaupovic Book 1987 The Editor(s) (if applicable) and The Author(s), under exclusive
描述Atherosclerosis which accounts in Western Europe for more than 40 % of deaths, is a generalized disease that develops slowly and is symptomless until lesions have become sufficiently severe to cause myocardial or cerebral infarction. Research on specific and precocious markers of atherosclerosis and the development of non invasive techniques for their early detection represent major challenges in biomedical field. We hope that this volume of edited papers, a consequence of the third international colloquium on atherosclerosis, conducted at the University of Brussels, Belgium through the support of the "Fondation de Recherche sur l‘ AtherosclE,rose" will contribute to this goal. Among the topics discussed the major ones were the mechanism of action of lipolytic enzymes, the deficiency or dysregulation of cellular receptors, the genetic deficiencies of apolipoproteins, and the panoply of external factors as diet, physical exercise, drugs, which mOdify the lipoprotein metabolism. Special interest was also devoted to potent techniques as kinetic analysis of metabolic tracers and use of monoclonal antibodies. Their contribution to the detection and treatment of atherosclerosis will be o
出版日期Book 1987
关键词enzymes; metabolism; protein; proteins; receptor
版次1
doihttps://doi.org/10.1007/978-1-4684-1268-0
isbn_softcover978-1-4684-1270-3
isbn_ebook978-1-4684-1268-0Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
The information of publication is updating

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发表于 2025-3-21 20:30:14 | 显示全部楼层
Separation and Identification of APO-B-Containing Lipoprotein Particles in Normolipidemic Subjects art [1,2]. The popularity of these classification systems has been enhanced by clinical studies which have related certain derangements of lipid transport to particular density classes or electrophoretic patterns [2,3]. However, the discovery of a number of apolipoproteins [1,4] and the detection of
发表于 2025-3-22 04:05:10 | 显示全部楼层
HDL Subfractions, HDL Receptors and HDL Turnoverlaupovic. proposed a distinction between so-called simple lipoproteins, containing only one apolipoprotein, and complex lipoproteins, containing more than one apolipoprotein. Recent publications show that isolation of plasma lipoproteins by ultracentrifugation may alter the apolipoprotein compositio
发表于 2025-3-22 05:38:01 | 显示全部楼层
Epitope Expression in Purified and Lipid-Bound forms of Human Apoprotein A–Iw avenues of research to be explored. With respect to lipoprotein metabolism, experimental strategies can be developed for studying structural and functional aspects of lipoprotein particles and examining how packaging of apoproteins into lipoproteins could influence their conformation and perhaps f
发表于 2025-3-22 11:12:14 | 显示全部楼层
Apolipoprotein D, Monoclonal Antibodies, and Cross-Reacting Proteinsveral laboratories, had noted the presence of two lines of immunoprecipitation in immunodiffusion experiments of human high density lipoproteins (HDL) and antiserum raised against these lipoproteins (2–5). One of these two immunoprecipitin lines was usually much narrowed than the other major line. B
发表于 2025-3-22 14:30:17 | 显示全部楼层
Characterisation and Mode of Inheritance of Apolipoprotein E3-Leidenconversion into low density lipoprotein (LDL) (Brown et al., 1981). The apolipoprotein E (apo E) present on lipoprotein remnants plays a central role in the hepatic metabolism of remnant particles as this apolipoprotein is recognized with high affinity by the hepatic receptors involved in remnant up
发表于 2025-3-22 19:23:37 | 显示全部楼层
Ag System Re-Explored: Studies with Monoclonal Anti-Apolipoprotein B Antibodies studies employing monoclonal anti-apoB antibodies have established a common polymorphism of apoB (2–4). The first report utilizing a direct binding assay (2) denied any connection between the classic Ag system of low density lipoproteins and the antibody-defined polymorphism of apoB. Using a differ
发表于 2025-3-23 00:47:36 | 显示全部楼层
Use of Combined Monoclonal Antibodies for the Immunochemical Determination of Apolipoproteins A–I an (LDL) appears to better correlate with the risk of coronary heart disease (CHD) as compared to plasma cholesterol levels while the cholesterol bound to high-density lipoprotein (HDL) is inversely related to the risk of developing CHD.
发表于 2025-3-23 04:11:33 | 显示全部楼层
Mechanism of Action of Lipoprotein Lipase and Hepatic Triglyceride Lipase triglyceride lipase (H-TGL) are lipolytic enzymes that play important roles in the clearance of lipoprotein triglycerides (1). In the absence of these enzymes, as occurs in the rare disorders of LpL deficiency or H-TGL deficiency, plasma triglycerides are elevated to levels greater than 1000 mg/dl.
发表于 2025-3-23 08:35:01 | 显示全部楼层
The Role of LCAT and Cholesteryl Ester Transfer Proteins for the HDL and LDL Structure and Metabolis plasma. Glomset(l) was first to describe in 1962 that phosphatidyl choline (lecithin) and free cholesterol (FC) are involved in this reactions LCAT transfers the fatty acid of position -2 of lecithin to the -OH group of free cholesterol yielding in lysolecithin and CE.
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