Titlebook: Lipoprotein Metabolism and Atherogenesis; Toru Kita (Professor),Masayuki Yokode (Assistant P Conference proceedings 2000 Springer-Verlag T

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Mitsuru Emi,Tsunenori Hirayama,Masahiro Tsuji,Akira Hata

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Paivi Pajukanta,Christian Ehnholm,Marja-Riitta Taskinen,Leena Peltonen

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Toru Kita (Professor),Masayuki Yokode (Assistant PPresenting the exciting results of research in the areas of the molecular basis of lipoprotein metabolism,.the link between lipoprotein metabolism disorder and atherogenesis, and the molecular approac

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Molecular Analysis on the LDL Receptors in Two Patients with Homozygous Familial Hypercholesterolemiint mutation in exon 7 and the other is a replacement of nine bases with completely different six bases in exon 8. Patient KZA is a true homozygote for a splice donor site mutation in intron 11. As expected from the sites of mutations, Patient NS retained some LDL receptor activity whereas Patient KZA showed no activity.

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Common Mutation of 5, 10-Methylenetetrahydrofolate Reductase Accelerates Coronary Artery Disease in s, only MTHFR genotype W was shown to be an independent predictor of the early onset of CAD. The mean plasma Hcy level of genotype W was significantly higher than those of the other two genotypes. These results suggest that he MTHFR mutation may accelerates the onset of CAD through elevation of plasma Hcy levels in male heterozygous FH patients.