Titlebook: Lipid Signaling Protocols; Banafshé Larijani,Rudiger Woscholski,Colin A. Ross Book 2009 Humana Press 2009 Cell function.Lipid analysis.Lip

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Measurement of Polyphosphoinositides in Cultured Mammalian Cellsponent of eukaryotic cell membranes. Nevertheless, their synthesis is needed for an ever-increasing spectrum of cellular processes, including regulation of the actin cytoskeleton, chemotaxis, membrane trafficking, glucose uptake, and organelle acidification. PPIn metabolism is regulated dynamically

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Methods for the Determination of the Mass of Nuclear PtdIns4,, PtdIns5,, and PtdIns(4,5),,undance, they form a dynamic signaling system that is regulated in response to a variety of extra- and intracellular cues [.]. Protein domains including PH, FYVE, ENTH, PHOX, PHD fingers, and lysine-/arginine-rich patches can bind to specific phosphoinositide isomers, which, in turn, can induce chan

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Solution and Solid-State NMR of Lipidsathways, as they are recognition sites at the membrane surface. Their head-group or chain structure appears to be crucial for such a signaling role. Other lipids such as cholesterol and sphingomyelin are key molecules in maintaining membrane integrity and are the building blocks of membrane domains,

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Effects of Sterols on the Development and Aging of ,es extensive enzymatic modification in . to form certain sterols of unknown function. Since sterol metabolism in . differs from that in other species, such as mammals and yeast, it is important to examine how sterols regulate worm physiology. To examine the functions of sterols in ., a sterol-feedin

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Proteomic Analysis of the Sterol-Mediated Signaling Pathway in , into cholesterol for cellular function. The inhibition of sterol conversion to cholesterol in . by various sterol biosynthesis inhibitors (SBIs) is known to cause serious defects in the development of these worms. To determine the biochemical consequences of these physiological abnormalities, one c