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Titlebook: Lethal Arrhythmias Resulting from Myocardial Ischemia and Infarction; Proceedings of the S Michael R. Rosen (Professor of Pharmacology and

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Calcium Current and Excitation-Contraction Coupling in Heartnces the time course and magnitude of the intracellular calcium transient. In addition to . contributing to the rise in intracellular calcium by means of its sarcolemmal calcium flux, I. may contribute . as the rise in intracellular calcium associated with the calcium flux triggers additional calciu
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Role of Cytosolic Calcium in the Normal and Ischemic Heart: Potential New Insights from the Second Gtation-contraction coupling, calcium ions regulate several different ionic currents that flow across the cell membrane. Inability of the ischemic myocardium to sequester or extrude calcium could have a variety of effects, the most serious of which would be the subversion of electrical activity in th
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Repetitive Activity: Origin of the Na+ Load and its Physiologic Effectstion potential, must be returned to their original site inside or outside the cell before the next beat. An obvious corollary of this steady state is that the concentrations of each of these ions in each intracellular and extracellular compartment remains unaltered.
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Ionic Changes Associated with Acute Ischemiaof the area deprived of its circulation. They then performed a series of experiments, which led them to conclude that the increase in extracellular potassium was a major factor, perhaps . major factor in the pathogenesis of the acute ventricular arrhythmias, including ventricular fibrillation, which
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Free Radicals and Myocardial Injury during Ischemia and Reperfusion: A Short-Lived Phenomenon?hese intermediates can play a major role in the pathophysiology of tissue injury in many organs and many disease processes. In the field of toxicology, agents such as paraquat, carbon tetrachloride, adriamycin, and alloxan, together with ionizing radiation and a whole range of chemical carcinogens (
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Receptor Mechanisms in Ischemia and Infarctioning cardiac function. Much has been learned in the last few years about the molecular mechanisms by which the autonomic nervous system regulates the heart. The components of the autonomic nervous system that regulate the heart include sympathetic and vagal nerve terminals, beta-adrenergic and muscar
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