Titlebook: Lentiviral Vectors and Gene Therapy; David Escors,Karine Breckpot,Holly Stephenson Book 2012 The Author(s) 2012 cancer.clinical trial.gene

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Development of Retroviral and Lentiviral Vectors, pathogen such as HIV into a successful therapeutic tool would not be possible without thorough scientific investigation into the development of .-retrovirus vectors. In this chapter, we briefly recapitulate the major scientific steps that have led to the development of .-retrovirus and lentivirus vectors.

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Clinical Grade Lentiviral Vectors,ults of several other trials were published. More recently, lentiviral vectors have been used for the correction of human .-thalassaemia and adrenoleukodystrophy. In this chapter, we discuss the production of clinical grade retro and lentivectors for their application in human therapy.

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Book 2012 could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century aft