Titlebook: Lehrbuch der pharmazeutischen Biologie; Ein Lehrbuch für Stu Rudolf Hänsel (Universitätsprofessor, emeritiert), Textbook 1996 Springer-Verl

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E. Teuscheronal neuronal systems of the PD brain are altered [2], the change most closely linked to the clinical symptomatology of Parkinsonism is the impaired generation of striatal dopamine. Dopamine production may also figure in the special vulnerability of substantia nigra pars compacta neurons in PD. Seve

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W. Axudied - and many biochemically-oriented scientists have devoted their research to the following questions: 1. What is the metabolic pathway that is inhibited selectively, and what are the target molecules within a sensitive cell? 2. What are the relationships between the chemical structure of an ant

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T. Dingermanns appear to have narrower spectra of selectivity. Thus lincomycin is very active on ribosomes from gram-positive bacteria and moderately active on blue-green algae ribosomes, but has low activity on ribosomes from gram-negative bacteria in preventing peptide bond formation (Chang and Weisblum, 1967;

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R. Hänselof these interactions could play key roles as both biological reagents and therapeutic compounds. However, much of the early work in this area with peptides revealed that these species, in general, bind with modest affinity to their protein targets. In addition, when these studies first commenced ne

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alling thresholds. CD45 substrates include Src tyrosine kinase family members, and in T cells both p56. and p59. are substrates. Src kinases such as p56. have negative regulatory C-terminus Tyr phosphorylation sites that are phosphorylated by the c-Src kinase and dephosphorylated by CD45, thereby sw

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