Titlebook: Lebensqualität im Alter; Therapie und Prophyl Rudolf Likar,Günther Bernatzky,Anton Sadjak Book 2017Latest edition Springer-Verlag GmbH Deut

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Günther Bernatzky,Horst-Peter Hesse (†),Gunter Kreutzoclonal antibodies classified as anti-PD-1 antibodies, anti-PD-L1 antibodies, CD27 agonists, anti-B7-H3 antibodies and anti-phosphatidyl serine antibodies are discussed. Next, different cytokine-based therapies administered as recombinant proteins, plasmid electroporation or virus based transfers ar

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Gerald Gattererls that tested the safety and efficacy of oncolytic viruses including T-VEC in melanoma patients are described. Then, Imlygic, the marketed formulation of T-VEC and its clinical pharmacology are discussed. The mechanism of action of T-VEC at cellular level is then explained followed by details of re

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Dieter Schmidtditing is introduced and then the various immune evasive mechanisms employed by cancer cells are discussed including, loss of T-cell recognition caused due to loss of MHC I expression and/or loss of antigen presenting machinery, inhibition of T-cell recruitment to the tumors, intrinsic resistance to

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Marina Kojertween the host and the tumor has been suggested. For this reason several forms of immunotherapy have been employed, resulting in a limited number of sometimes long-lasting responses [23]. Most emphasis has been given to those forms of immunotherapy which induce stimulation of the immune-effector sys

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Karl Cernic,Ernst J. Müller,Olivia Kadarelationship, and toxicity profile of these drugs. This chapter provides an overview of the pharmacokinetics (PK), pharmacodynamics (PD), and toxicity of the current immune checkpoint inhibitors as monotherapy and in combination. Collaborative work of basic scientists, clinical pharmacists, and onco

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