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Titlebook: Late Graft Loss; Proceedings of the 2 J. L. Touraine,J. Traeger,C. Dupuy Conference proceedings 1997 Springer Science+Business Media Dordre

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书目名称Late Graft Loss
副标题Proceedings of the 2
编辑J. L. Touraine,J. Traeger,C. Dupuy
视频video
丛书名称Transplantation and Clinical Immunology
图书封面Titlebook: Late Graft Loss; Proceedings of the 2 J. L. Touraine,J. Traeger,C. Dupuy Conference proceedings 1997 Springer Science+Business Media Dordre
描述In all varieties of organ transplants, early results havedramatically improved over the past two decades and failures due toacute rejection are becoming rarer. Efficient immunosuppressiveregimens have been developed with the objective of very good resultsat 1, 3 and 5 years. .Successful transplants, however, are significantly less frequent at 10and 20 years, and many patients require retransplantation. Manyfactors are involved in late graft loss and it is now well recognizedthat, in addition to chronic rejection, a number of non-immunologicfactors play a prominent role. In the case of renal transplantation, areduced mass loss (transplantation of a single kidney, sometimes froman aged donor, ischemic injury and alteration of some nephrons in thecase of early acute rejection) will result in slowly progressingchronic renal failure, even in the absence of any supplementary attackof an immunological nature. The new treatments must be analyzed in thelight of their capacity to reduce these late failures. Severalpreventive measures can also limit both immunologic andnon-immunologic factors of late transplant deterioration.
出版日期Conference proceedings 1997
关键词biopsy; blood; clinical trial; immunosuppression; infection; infections; kidney; liver transplantation; lymp
版次1
doihttps://doi.org/10.1007/978-94-011-5434-5
isbn_softcover978-94-010-6286-2
isbn_ebook978-94-011-5434-5
copyrightSpringer Science+Business Media Dordrecht 1997
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The impact of acute rejection on the long-term outcome after renal transplantation, 2]. In a recently published analysis, we found that the negative impact of a single rejection on the one-year graft survival rate was limited but that this negative effect significantly increased when more than one rejection occurred [3]. Only a few studies, however, have analyzed the impact of acute rejection on the long-term outcome.
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Late graft loss in combined kidney-pancreas transplantationstage renal disease in type 1 diabetes mellitus patients [1]. A decreased rate in technical failures combined with improved immunosuppression and intensive care has increased one-year pancreas graft survival.
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Longterm allograft outcome in patients treated with prophylactic antilymphocyte globulin or OKT3 as A) has decreased the incidence of acute rejection episodes and, consequently, the proportion of grafts lost during the first year after transplantation [1]. However, longterm results have not reflected the same progress since, in most registries, the yearly rate of grafts lost beyond the first year has remained unchanged [2].
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Chronic graft loss in kidney and heart transplant recipientsWhereas the rate of acute immunological transplant rejection has been reduced during the last decade thanks to the introduction of highly effective immunosuppressive regimens, the rate of late graft loss remains a major challenge. Chronic graft loss is affected both by immunological and nonimmunological factors.
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https://doi.org/10.1007/978-94-011-5434-5biopsy; blood; clinical trial; immunosuppression; infection; infections; kidney; liver transplantation; lymp
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