书目名称 | Laron Syndrome - From Man to Mouse | 副标题 | Lessons from Clinica | 编辑 | Zvi Laron,J. Kopchick | 视频video | http://file.papertrans.cn/582/581438/581438.mp4 | 概述 | First book covering this interesting topic, written by Zvi Laron who first described and reported the condition in 1966 (this syndrome is named after him).Describes the comprehensive pathophysiology o | 图书封面 |  | 描述 | Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions. | 出版日期 | Book 2011 | 关键词 | Effects on Aging; GH inactivity; GH insensitivity; GH receptor gene disruption; GH resistance; IGF-treatm | 版次 | 1 | doi | https://doi.org/10.1007/978-3-642-11183-9 | isbn_softcover | 978-3-662-50171-9 | isbn_ebook | 978-3-642-11183-9 | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
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