| 书目名称 | Lactoferrin and its Role in Wound Healing |
| 编辑 | Yoshiharu Takayama |
| 视频video | |
| 概述 | Provides the recent advances in molecular mechanisms of wound healing.Provides in-depth information on roles of lactoferrin as a signaling molecule.Presents the scientific background on use of lactofe |
| 图书封面 |  |
| 描述 | Lactoferrin is an iron-binding glycoprotein belonging to the transferrin family. It acts as a defense in host animals against microbes and viruses, since it has a broad spectrum of antimicrobial and antiviral activities. Lactoferrin has been shown to regulate the growth and differentiation of many types of cells.The results of recent studies indicate that lactoferrin is a potent regulator of dermal fibroblasts, and promotes cutaneous wound healing.The collagen gel contraction, a model of wound contraction during wound healing process, and migration of human fibroblasts were enhanced by lactoferrin. LRP-1 (LDL Receptor related Protein-1) acts as a signaling receptor for lactoferrin that mediate fibroblast response to lactoferrin by activating ERK/MAPK signaling pathway.In addition, lactoferrin promotes biosynthesis of extracellular matrix (ECM) component such as type-I collagen and hyaluronan. Hyaluronan is a major component of ECM in connective tissue and promotes wound healing. The promoting effect of lactoferrin on hyaluronan production was accompanied by promotion of HAS2 (hyaluronan synthase 2) expression. These observations suggest that lactoferrin promotes the wound healing b |
| 出版日期 | Book 2012 |
| 关键词 | Granulation tissue; Hyaluronan; Lactoferrin; Reepithelialization; Wound Healing; Receptors |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-94-007-2467-9 |
| isbn_softcover | 978-94-007-9202-9 |
| isbn_ebook | 978-94-007-2467-9 |
| copyright | Springer Science+Business Media B.V. 2012 |
发表于 2025-3-21 16:58:10
