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Titlebook: Label-Free Biosensor Methods in Drug Discovery; Ye Fang Book 2015 Springer Science+Business Media New York 2015 Biotechnology.Cell signali

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书目名称Label-Free Biosensor Methods in Drug Discovery
编辑Ye Fang
视频video
概述Assists academic and industrial researchers involved in drug and probe discovery to adopt label-free techniques.Provides fundamental and practical methods from expert researchers.Includes tips and key
丛书名称Methods in Pharmacology and Toxicology
图书封面Titlebook: Label-Free Biosensor Methods in Drug Discovery;  Ye Fang Book 2015 Springer Science+Business Media New York 2015 Biotechnology.Cell signali
描述.This volume explores label-free biosensors, advantageous in part because this technology bypasses the need of labels, reporters, and cell engineering, all of which are common to labeled techniques but may introduce artifacts in assay results. Addressing several fundamental and practical aspects as to how to implement label-free methods in the drug discovery process, this book covers a wide range of topics, including binding kinetics determination, fragment screening, antibody epitope mapping, protein-protein interaction profiling and screening, receptor pathway deconvolution, drug pharmacology profiling and screening, target identification, drug toxicity assessment, and physical phenotype profiling and diagnostics based on various cellular processes such as cell adhesion, migration, invasion, infection, and inflammation. As part of the .Methods in Pharmacology and Toxicology. series, chapters aim to provide key detail and implementation advice to aid with progress in the lab..Practical and thorough, .Label-Free Biosensor Methods in Drug Discovery. provides a new avenue for rapid access to a focused collection of highly regarded contributions in the field..
出版日期Book 2015
关键词Biotechnology; Cell signaling; Clinical diagnostics; Drug safety assessment; Drug screening and profilin
版次1
doihttps://doi.org/10.1007/978-1-4939-2617-6
isbn_softcover978-1-4939-4961-8
isbn_ebook978-1-4939-2617-6Series ISSN 1557-2153 Series E-ISSN 1940-6053
issn_series 1557-2153
copyrightSpringer Science+Business Media New York 2015
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Label-Free Technologies: Which Technique to Use and What to Watch Out for!to drug action. In this chapter we review the fundamentals of drug action in a biological system, the physical basis of different label-free systems, and then discuss the advantages and artifacts associated with each technique. We hope that this will help guide the reader towards a rational choice o
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Silicon Photonic Micro-Ring Resonators for Drug Screening and Kinetic Analysisimultaneously to quantify the presence of analytes. Currently, each assay is performed in quadruplicate, with 2 flow channels per chip, providing 15 multiplexed assays plus 1 control in each channel. Twelve chips are packaged into a consumable cartridge that can measure 24 samples. A 96-well plate w
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Multiplexing Label-Free and Fluorescence-Based Methods for Pharmacological Characterization of GPCR uted by multiple signaling pathways may also be required to complement label-based assays that target specific signaling events. For this purpose, the effects mediated by GPCRs may be measured by dynamic mass redistribution (DMR) through Resonant Waveguide Grating (RWG) biosensors embedded in 384-we
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