Titlebook: LC-MS in Drug Analysis; Methods and Protocol Loralie J. Langman,Christine L.H. Snozek Book 2019Latest edition Springer Science+Business Med

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Targeted Opioid Screening Assay for Pain Management Using High-Resolution Mass Spectrometry,noassay screening tests, which suffer from a lack of sensitivity and specificity, to verify compliance to pain medications. However, several immunoassay tests are required to comprehensively detect the synthetic, semisynthetic, and natural opioids due to the limited cross-reactivity of each assay. S

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LC-MS/MS Method for the Quantification of the Leflunomide Metabolite, Teriflunomide, in Human Serumd decrease the synthesis of pyrimidine nucleotides for DNA and RNA synthesis. Teriflunomide is primarily used for the treatment of rheumatoid arthritis and multiple sclerosis..A liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed and validated to quantify the drug teriflun

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Analysis of Tryptic Peptides from Therapeutic Monoclonal Antibodies Using LC-MS/MS,tic monoclonal antibodies (mAbs) are part of this revolution, and clinical chemists are aware of the success of the biologic drugs. Antibodies are not just immunoassay reagents anymore but are also present in clinical serum samples from more and more patients each day. The clinical laboratory will h

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Simultaneous Determination of Tacrolimus and Cyclosporine A in Whole Blood by Ultrafast LC-MS/MS,have previously been described. The majority of these methods use solid-phase extraction, liquid-liquid extraction, or protein precipitation extraction with instrument run times greater than 15 s per sample. Continued demands in clinical labs for greater efficiency and throughput have put increased

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The Evolving Landscape of Designer Drugs, psychoactive substances” (NPS), these substances are used for their pharmacological effects which are often similar to more widely known drugs such as ecstasy or heroin. In some cases users specifically seek out these new chemicals, in other cases they are simply purchasing what they believe to be

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Analysis of Synthetic Cannabinoid Metabolites by Liquid Chromatography-Tandem Mass Spectrometry,nt compounds in circulation at any given time is constantly in flux, changing at a rapid rate to avoid legal control and to a lesser extent to avoid detection. Even with knowledge of the chemical entities, their detection in urine is complicated by the fact that they are present exclusively as both