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Titlebook: Knowledge Discovery and Emergent Complexity in Bioinformatics; First International Karl Tuyls,Ronald Westra,Ann Nowé Conference proceeding

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Advancing the State of the Art in Computational Gene Prediction, probabilistic, state-based generative models such as hidden Markov models and their various extensions. Unfortunately, little attention has been paid to the optimality of these models for the gene-parsing problem. Furthermore, as the prevalence of alternative splicing in human genes becomes more ap
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Analyzing Stigmergetic Algorithms Through Automata Games,ing for use in multi-agent systems, as it provides a simple framework for agent interaction and coordination. However, determining the global system behavior that will arise from local stigmergetic interactions is a complex problem. In this paper stigmergetic mechanisms are modeled using simple rein
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The Identification of Dynamic Gene-Protein Networks,h with special interest for partitioned state spaces. From the observation that the dynamics in natural systems tends to punctuated equilibria, we will focus on piecewise linear models and sparse and hierarchic interactions, as, for instance, described by Glass, Kauffman, and de Jong. Next, the pape
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Sparse Gene Regulatory Network Identification,od uses mixed . ./. . minimization: nonlinear least squares optimization to achieve an optimal fit between the model in state space form and the data, and . .-minimization of the parameter vector to find the sparsest such model possible. In this approach, in contrast to previous research, the dynami
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Boolean Algebraic Structures of the Genetic Code: Possibilities of Applications, acceptors in DNA sequences. Besides, pure mathematical models, Statistical techniques (Decision Trees) and Artificial Intelligence techniques (Bayesian Networks) were used in order to show how to accomplish them to solve these knowledge-discovery practical problems.
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Discovery of Gene Regulatory Networks in ,,mining in the gene descriptions and evaluating gene ontology terms. The expression profiles of these genes were simulated by a differential equation system, whose structure and parameters were optimized minimizing both the number of non-vanishing parameters and the mean square error of model fit to the microarray data.
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