Titlebook: Kinins; Pharmacodynamics and Federigo Sicuteri,Nathan Back,Gert L. Haberland Book 1976 The Editor(s) (if applicable) and The Author(s), und

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A Sensitive Kinin Liberating Assay for Kininogenase in Rat Urine, Isolated Glomeruli and Tubules ofes (1, 2, 3, 4, 5, 6, 7). A prerequisite to evaluate the significance of the system, is the possibility of measuring kallikrein activities in tissues, where it is formed, excreted and inactivated. Recently Nustad and Pierce (8) showed, that the rat kidney synthesizes four kallikreins, which are rele

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Inhibitors of Kinin-Forming Enzymes,inase, and so on. Among them plasmin and kallikrein have kinin-forming activity. A synthetic reversible inhibitor of plasmin, and anticoagulant factor of blood, has been extensively studied. The first effective fibrinolytic inhibitor, ε-aminocaproic acid (εACA) was discovered by Okamoto, .. in 1958

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Mechanism of the Sialagogic Effect Induced by Bradykinin in Dogs: Possible Mediation by Endogenous It is unaffected by hexamethonium (2 mg/kg, i.v.) and is still present in chronically denervated glands. The effect is abolished by atropine (1 mg/kg, i.V.), morphine (10 μg/kg, i.v.) or following the ganglionic block by depolarization induced by nicotine (1 mg) by intracarotideal route.

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,Which is the Effective Agent — Bradykinin or Prostaglandins — on the Isolated Mammalian Heart,Va., last October, the question was raised whether the effects of bradykinin (Bk) on the isolated mammalian heart perfused by the Langendorff technique, could be due to a release of prostaglandin (PGE.), since the latter was able to produce a similar effect on the coronary perfusion flow and on the

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The Primary Structure of Pig Pancreatic Kallikrein B,ith neuraminidase to remove bound sialic acids. After reductive cleavage of the disulfide bridges and carboxymethylation, two peaks of UV-absorbing material could be separated by gel filtration on Sephadex G-75 in 50% acetic acid. According to gel electrophoresis, both were essentially homogeneous.

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