Titlebook: Kidney Development and Disease; Rachel K. Miller Book 2017 Springer International Publishing AG 2017 Kidney development.Kidney disease.Nep

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Genetic Syndromes Affecting Kidney Developmentith single gene and renal developmental defects are less common but have facilitated insight into the mechanism of renal and other organ development. Analysis of underlying genetic mutations with transgenic and mutant mice has also led to advances in our understanding of mechanisms of renal development.

惰性气体

Malpighian Tubules: A Model for Understanding Kidney Development, Function, and Disease process. They are functional analogs of human kidneys which are important physiological organs as they maintain water and electrolyte balance in the blood and simultaneously help the body to get rid of waste and toxic products after various metabolic activities. In addition, it receives early indic

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gene-therapy

Zebrafish as a Model of Kidney Diseaseons of disease pathology. The zebrafish (.) is a good alternative to mammalian models that can be used to apply powerful genetic experimental methods normally used in invertebrates to answer questions about vertebrate development and disease. In the case of the kidney, the zebrafish has proven itsel

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锯齿状

Tissue-Specific Functions of p53 During Kidney Developmentefutable involvement in restraining unchecked cell proliferation, research over the past several years has indicated a requirement for p53 function in sustaining normal development. Here I summarize the role of p53 in embryonic development, with a focus on knowledge gained from p53 loss and overexpr

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Growth Factor Regulation in the Nephrogenic Zone of the Developing Kidney of the kidney. This leading edge of active nephron induction is known as the nephrogenic zone. Cell populations found within this zone include collecting duct tips, cap mesenchyme cells, pretubular aggregates, nephrogenic zone interstitium, hemoendothelial progenitor cells, and macrophages. The clo

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Development and Diseases of the Collecting Duct Systemlly and functionally distinct cell types: principal cells and intercalated cells. The former regulates Na. and water homeostasis, while the latter participates in acid–base homeostasis. In vivo lineage tracing using Cre recombinase or its derivatives such as CreGFP and CreER. is a powerful new techn

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Origin and Function of the Renal Stroma in Health and Diseasehe renal capsule, glomerulus, vasculature, and interstitium. In this chapter, we review published evidence defining what, where, and why stromal cells are important. We describe the functions of the renal stroma andhow stromal derivatives are crucial for normal kidney function. Next, we review the s

SMART

Imaging, Analysing and Interpreting Branching Morphogenesis in the Developing Kidney factors which serve to ensure two kidneys form in the appropriate positions in the body. At its simplest level, kidney development can be viewed as the process by which this single bud then undergoes a process of arborisation to form a complex connected network of ducts which will serve to drain ur