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Titlebook: Issues in Clinical Epileptology: A View from the Bench; Helen E. Scharfman,Paul S. Buckmaster Book 2014 The Editor(s) (if applicable) and

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书目名称Issues in Clinical Epileptology: A View from the Bench
编辑Helen E. Scharfman,Paul S. Buckmaster
视频video
概述Discussion of current debates in epilepsy research.Authors are leaders in the field of epilepsy and neuroscience.Basic and clinical research opinions are combined.Content provides a perspective on pas
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Issues in Clinical Epileptology: A View from the Bench;  Helen E. Scharfman,Paul S. Buckmaster Book 2014 The Editor(s) (if applicable) and
描述This book is dedicated to Dr. Philip A. Schwartzkroin. The book has a novel format because it is not intended to be a set of reviews. Instead, it is an effort to explore important topics in the epilepsy research field. Because articles are written by leaders in the field who have years of experience and individuals with diverse expertise, articles are likely to have a long-lasting impact and be relevant for both epileptologists and neuroscientists. Authors address topics that are important, unresolved questions in the field of epilepsy research, drawing on available data from both the bench and the clinic to support their points. A given topic is addressed by one or more authors, each writing from his/her own unique perspective. For all of the individuals who have been trained or worked with Philip Schwartzkroin in the past and/or have appreciated his contributions to the epilepsy field, this volume is an excellent way to celebrate his achievements and look to the ways they have moved the field forward and continue to stimulate its growth.
出版日期Book 2014
关键词Anticonvulsant drug; Epilepsy; Epileptogenesis; Seizure; Translation
版次1
doihttps://doi.org/10.1007/978-94-017-8914-1
isbn_softcover978-94-024-0789-1
isbn_ebook978-94-017-8914-1Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature B.V. 201
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What Is the Clinical Relevance of , Epileptiform Activity?e many new avenues of epilepsy research such as vascular, astrocytic and mitochondrial contributions to epileptogenesis. Rigorous study design as well as close collaboration with in vivo laboratories and clinical investigators will accelerate the translation of the exciting discoveries that will be
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What Is a Seizure Network? Very Fast Oscillations at the Interface Between Normal and Epileptic Brain inhibitory interneurons, then the stage is set for synchronized bursting – if [Ca.]. recovers sufficiently. Our hypothesis can be tested (in part) in patients, once it is possible to measure brain tissue parameters (pH, [Ca.].) simultaneously with ECoG.
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When and How Do Seizures Kill Neurons, and Is Cell Death Relevant to Epileptogenesis?neuronal death may be necessary for epileptogenesis is based on the ., where a loss of synaptic input from the dying neurons is considered a critical signal to induce axonal sprouting and synaptic-circuit reorganization. We propose a second hypothesis – the ., which states that the biochemical pathw
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Is Plasticity of GABAergic Mechanisms Relevant to Epileptogenesis?togenesis) difficult to understand mechanistically, and difficult to treat. We also suggest that this complexity arises, at least in part, because of the remarkable plasticity of GABAergic neurons and GABA. receptors in response to insult or injury.
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