Titlebook: Isoprenoid Synthesis in Plants and Microorganisms; New Concepts and Exp Thomas J. Bach,Michel Rohmer Book 2013 Springer Science+Business Me

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Microbially Derived Semisynthetic Artemisinin,t of malaria in artemisinin combination therapies (ACTs). It is extracted from the plant ., but its supplies are limited and its price is volatile. In order to increase supply and stabilize the price of artemisinin, a semisynthesis has been developed, whereby an artemisinin precursor (amorpha-4,11-d

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Fosmidomycin as an Antimalarial Agent,tol 4-phosphate (MEP) pathway [also known as the 1-deoxy-.-xylulose 5-phosphate (DXP) pathway]. The enzymes of the MEP pathway of . are located in a plastid-like organelle called the apicoplast. The growth of . parasites is rapidly inhibited by fosmidomycin, an inhibitor of DXP reductoisomerase. The

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Involvement of Compartmentalization in Monoterpene and Sesquiterpene Biosynthesis in Plants,tion. The biosynthesis of terpenoids in plants occurs in different subcellular compartments, which until recently were believed to include the cytosol, plastids, and mitochondria. The plastidic MEP pathway and the cytosolic MVA pathway give rise to IPP and DMAPP, which are subsequently utilized by p

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Strategies for the Manipulation of Carbocations by Aristolochene Synthase,lochene via a tightly chaperoned carbocationic reaction cascade. This article examines recent work focussed on understanding the role this and other related enzymes play in controlling this chemistry. Through the use of X-ray crystallography, site-directed mutagenesis and substrate analogues, a bett

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Strigolactones: A Cry for Help Results in Fatal Attraction. Is Escape Possible?,n active process during which the plant needs to respond to many different stimuli in order to survive..For example, plants have developed an array of physiological and biochemical responses to phosphate deprivation. One of these responses is the production of isoprenoid-derived molecules called str