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Titlebook: Is Crohn’s Disease a Mycobacterial Disease?; Chris J. J. Mulder,Guido N. J. Tytgat Book 1992 Springer Science+Business Media Dordrecht 199

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书目名称Is Crohn’s Disease a Mycobacterial Disease?
编辑Chris J. J. Mulder,Guido N. J. Tytgat
视频video
丛书名称Developments in Gastroenterology
图书封面Titlebook: Is Crohn’s Disease a Mycobacterial Disease?;  Chris J. J. Mulder,Guido N. J. Tytgat Book 1992 Springer Science+Business Media Dordrecht 199
描述IS CROHN‘S DISEASE A MYCOBACTERIAL DISEASE‘! The fact that the differential diagnosis of inflammatory bowel disease includes intestinal infections has been a source of much interest and clinical concern for many years. Since the recognition of ulcerative colitis and Crohn‘s disease as clinical entities, numerous attempts have been made to identify a specific organism resulting in the clinical and pathologic picture of Inflammatory Bowel Disease. The first suggestion about a connection between Johne‘s disease, a chronic mycobacterial enteritis in cattle, and Crohn‘ s disease occurred in 1913, when Dalziel described enteritis in humans which, although resembling intestinal tuberculosis, he believed to be a new disorder. Since the work of Crohn in the thirties a few investigators attempted to look for mycobacteria in Crohn‘s disease. Until now the work of Van Patter, Burnham and others did not receive widespread recognition. In 1984 the isolation of M. paratuberculosis was reported by Chiodini et al. This report initiated the current interest and controversy about a mycobacterial etiology in Crohn‘s disease. The hypothesis "Crohn‘s disease is Johne‘s disease" did not receive widesprea
出版日期Book 1992
关键词antigen; diagnosis; immunotherapy; infection; tuberculosis
版次1
doihttps://doi.org/10.1007/978-94-011-1830-9
isbn_softcover978-94-010-4808-8
isbn_ebook978-94-011-1830-9
copyrightSpringer Science+Business Media Dordrecht 1992
The information of publication is updating

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,Immunotherapeutical Approaches to Crohn’s Disease in View of a Possible Pathogenic Role of Mycobactls: B- and T-lymphocytes, plasma cells, macrophages, mast cells, eosinophils and basophils. In normal subjects the majority of the B-cells are committed to IgA synthesis (90%), the residual 10% being represented (in order of decreasing frequency) by IgM, IgG, IgE and IgD producing plasma cells. Thes
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,Immunotherapeutical Approaches to Crohn’s Disease in View of a Possible Pathogenic Role of Mycobactlly results in systemic tolerance. Changes in these immunological processes, caused by an altered mucosal barrier, an abnormal antigen-antibody or antigen-antigen presenting cell response, may play a role in the pathogenesis of Crohn’s disease.
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