| 书目名称 | Iron Chelation Therapy | | 编辑 | Chaim Hershko | | 视频video | | | 丛书名称 | Advances in Experimental Medicine and Biology | | 图书封面 |  | | 描述 | Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present | | 出版日期 | Book 2002 | | 关键词 | Handling; Malaria; cancer therapy; cell; development; evolution; homeostasis; iron; molecular basis; pathophy | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4615-0593-8 | | isbn_softcover | 978-1-4613-5148-1 | | isbn_ebook | 978-1-4615-0593-8Series ISSN 0065-2598 Series E-ISSN 2214-8019 | | issn_series | 0065-2598 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
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发表于 2025-3-21 19:20:06
