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Titlebook: Ion Channels in Biophysics and Physiology; Lei Zhou Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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发表于 2025-3-21 16:34:50 | 显示全部楼层 |阅读模式
书目名称Ion Channels in Biophysics and Physiology
编辑Lei Zhou
视频video
概述Provides an overview of relatively recent and significant topics in the field of ion channel research.Promotes the understanding of protein biophysics through the research on ion channels.Sheds light
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Ion Channels in Biophysics and Physiology;  Lei Zhou Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license to
描述.This book gathers relatively recent and significant topics in the field of ion channel research. Ion channels form the molecular basis for membrane excitability in cells present in the cardiovascular and nervous systems. In many non-excitable cells, ion channels contribute to diverse physiological functions, including the secretion of signaling compounds like hormones and insulin, cell volume regulation, intracellular signaling, especially Ca2+ signaling, etc. Many human diseases have been attributed to abnormal channel functions and defective membrane expression of channel proteins. On the other hand, ion channels are excellent models for studying protein biophysics, especially the allosteric regulation of protein function by miscellaneous stimuli. Therefore, research on ion channels carries significant meaning for the understanding of basic protein biophysics and diverse physiological functions. Such vital information also assists in developing novel and effective treatmentsfor related human diseases. This book provides graduates and scientists in both basic and clinical levels a comprehensive understanding of cutting-edge advances and a useful and stimulating platform for tackl
出版日期Book 2021
关键词Ion channel families; Biophysics mechanism of ion channels; Theoretical and experimental approaches fo
版次1
doihttps://doi.org/10.1007/978-981-16-4254-8
isbn_softcover978-981-16-4256-2
isbn_ebook978-981-16-4254-8Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapor
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发表于 2025-3-21 23:34:21 | 显示全部楼层
Ion Channels in Biophysics and Physiology: Methods & Challenges to Study Mechanosensitive Ion Channethinning, compression, expansion, and shear, and thus, have components in many strain dimensions. In addition, due to the viscoelastic nature of cells, these deformations may have linear and nonlinear components. In spite of these experimental challenges, Sukharev et al. cloned the first mechanosens
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The Polysite Pharmacology of TREK K2P Channelsinhibitor site), at the level of (K. modulator pocket), and below (Fenestration and Modulatory lipid sites) the C-type selectivity filter gate that is at the heart of K. function. Uncovering this rich structural landscape provides the framework for understanding and developing subtype-selective modu
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Calcium Channel Splice Variants and Their Effects in Brain and Cardiovascular Function of Ca.1.2/Ca.1.3 such as phosphorylation and ubiquitination. Deviation from this physiological range will result in deleterious effects known as calcium channelopathies, some of which will be explored in this chapter.
发表于 2025-3-22 11:12:37 | 显示全部楼层
DEG/ENaC Ion Channels in the Function of the Nervous System: From Worm to Mane vast majority of the channel’s extracellular domain is conserved across different members and species; however, key changes including the insertion of extra loops near the finger and palm domains most likely confers gating specificity. Indeed, DEG/ENaC channels are gated by a wide range of stimuli
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TRPV1 in Pain and Itchl pharmaceutical target. Over decades, the basis of TRPV1 channel structure, the nature of its activity, and its modulation in pathological processes have been broadly studied and well documented. Herein, we highlight the role of TRPV1 and its associated neurons in sensing pain and itch. The fundame
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