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Titlebook: Introduction to Virology; K. M. Smith Book 1980 K.M. Smith and D.A. Ritchie 1980 cell.cell culture.fungi.gene.gene expression.genetics.inf

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The replication of viruses,to the dynamic, metabolically active intracellular form of the virus. A common outcome of infection is multiplication of the virus with the concomitant death of the host cell. This is the productive cycle of virus infection. There are alternative modes of interaction in which the virus exists with t
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Virus genetics,ts (mutants) provide the basic stock in trade for genetic analysis as well as being the source of variation through which evolution occurs. By examination of the defects arising from infection of cells by mutant virus it is possible to identify virus-coded functions and so build up a comprehensive p
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Tumour viruses, is gradually disappearing. No one now speaks of a ‘milk factor’ with reference to the vivus causing mammary cancer in mice or the ‘agent’ with reference to the Rous sarcoma virus. It was the work carried out on these tumours which finally swept away all conceptions of ‘factors’ and ‘agents’.
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Virus assay, ‘Local lesions’, and ‘Plaque assay’ in the case of animal viruses, the lesions consisting of small areas of cell destruction. For plaque assay cell culture is the essential factor, whereas special plants are used for the local lesion technique. In both cases it is necessary that the lesions remain
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