Titlebook: Introduction to Modeling Biological Cellular Control Systems; Weijiu Liu Textbook 2012 Springer-Verlag Italia Srl. 2012 Biochemical proces

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Weijiu Liues. It is a timely response to the ongoing crises and pressing challenges that inhabitants of cities, towns, and villages worldwide are faced with in the midst of what has been widely dubbed as ‘an urban age’. Starting from the premise that current urban development patterns are unsustainable in eve

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Overview,nisms so that cells in the living organisms can carry out numerous functions to survive. In this textbook, I select a number of cellular control systems that I have understood most to demonstrate how to model them mathematically in the setting of control theory.

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Enzyme Kinetics,erted into products, but the enzymes themselves are not changed. An enzyme is usually a large protein, considerably larger than its substrate molecules. An enzyme protein has one or more active sites, to which its substrates can bind to form a complex. Enzymes are highly specific, usually catalyzing

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Control of Blood Glucose,n and nerve cells (insulin-independent) via the glucose transporter 3 (GLUT3) or by tissue cells such as muscle, kidney, and fat cells (insulin-dependent) via the glucose transporter 4 (GLUT4). Glucose is transported into and out of liver cells by the concentrationdriven glucose transporter 2 (GLUT2

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Control of Calcium in Yeast Cells, of 50 – 200 nM by means of a feedback control system [1, 16, 23]. The rise of cytosolic calcium activates calmodulin which in turn activates the serine/threonine phosphatase calcineurin (Fig. 5.1). The activated calcineurin de-phosphorylates Crz1p and suppresses the activity of Vcx1p. Activated Crz

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Kinetics of Ion Pumps and Channels,um channels, voltage-gated calcium channels, sodium/calcium exchangers, and plasma membrane (PM) calcium ATPases, as demonstrated in Fig. 6.1. Calcium ions Ca. enter the cytosol through store-operated channels (SOC) and voltage-gated calcium channels (VGCC). The sarcoplasmic or endoplasmic reticulum

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