| 书目名称 | Intrinsically Disordered Proteins Studied by NMR Spectroscopy |
| 编辑 | Isabella C. Felli,Roberta Pierattelli |
| 视频video | |
| 概述 | Focuses on Intrinsically Disordered Proteins studied by NMR Spectroscopy.Chapters written by partners of the Marie Curie Initial Training Network.The study of intrinsically disordered proteins has see |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | .This book discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). The properties of IDPs and IDPRs are highly complementary to those deriving from the presence of a unique and well-defined three-dimensional fold. Ignored for a long time in high-resolution studies of proteins, intrinsic protein disorder is now recognized as one of the key features for a large variety of cellular functions, where structural flexibility presents a functional advantage in terms of binding plasticity and promiscuity and this volume explores this exciting new research..Recent progress in the field has radically changed our perspective to study IDPs through NMR: increasingly complex IDPs can now be characterized, a wide range of observables can be determined reporting on the structural and dynamic properties, computational methods to describe the structure and dynamics are in continuous development and IDPs can be studied in environments as complex as whole cells. This volume communicates the new exciting possibilities offered by NMR and presents open questions to foster further developments. |
| 出版日期 | Book 2015 |
| 关键词 | NMR spectroscopy; bioinformatics; functional IDP regions; intrinsically disordered proteins; nuclear mag |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-20164-1 |
| isbn_softcover | 978-3-319-37117-7 |
| isbn_ebook | 978-3-319-20164-1Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
发表于 2025-3-21 19:08:13
