Titlebook: Intrinsic mutagenesis; A genetic approach t Macfarlane Burnet Book 1974 Sir Macfarlane Burnet 1974 ageing.atherosclerosis.bacteria.biology.

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978-94-011-6608-9Sir Macfarlane Burnet 1974

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The Two Imperativesntages to the species. The thesis of this essay is that both requirements are solved genetically by methods which involve control of mutability in the broad sense. For survival there must be an adequate appearance of mutants to ensure possibilities of adjusting to changes in the ecosystem or occupyi

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Intrinsic Mutagenesis: An Elementary Discussion at the Level of Molecular BiologyRNA. Damage by radiation, by free radicals, and by chemical molecules reactive with DNA is constantly occurring. At intervals the whole fantastic process of mitosis, with all its possibilities of breaks, wrong connections, and so on, is initiated and completed. Every one of these functions requires

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Mutation in Evolutionre in normal circumstances quantitatively unimportant and for the most part effective only through their influence on the errors in DNA replication of intrinsic origin. Under these circumstances it is inevitable that discussion should centre first on the most readily measured mutagen and the one wit

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Somatic Mutations Not altogether unreasonably, workers in the experimental biomedical sciences have resisted accepting hypotheses ascribing bodily phenomena, physiological or pathological, to somatic mutation. The objection was essentially that any hypothesis ascribing a phenomenon to a change taking place in a . is

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The Thymus in Relation to Ageing. Enough direct evidence is available that various measurable functions of the immune system show progressive weakening and inefficiency with age. Presumably this must in some way be related to accumulating somatic mutational changes in lymphocytes and their derivates, perhaps particularly in T-immu