Titlebook: Intrinsic Immunity; Bryan R. Cullen Book 2013 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag

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RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants,cesses, such as genome defense against mobile DNA elements or regulation of factors involved in plant and animal development. In higher plants and invertebrates, it also functions as a powerful antiviral mechanism. To overcome antiviral RNAi, viruses have evolved suppressor proteins which counteract

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Roles of MicroRNAs in the Life Cycles of Mammalian Viruses,ced silencing complexes to modestly repress mRNAs with imperfect sequence complementarity. Over the last years, many different roles of miRNA mediated regulation in the life cycles of mammalian viruses have been uncovered. In this chapter, I will mainly explore four different examples of how cellula

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Interplay Between DNA Tumor Viruses and the Host DNA Damage Response,vercome is recognition of viral DNA structures by the host DNA damage response (DDR) machinery. This is accomplished in elegant and unique ways by different viruses as each has specific needs and sensitivities dependent on its life cycle. In this review, we focus on three DNA tumor viruses and their

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Bryan R. CullenWritten by leading experts in the field.Provides a better understanding of the co-evolution of viral pathogens and their hosts.Offers perspectives for the design of antiviral drugs.Includes supplement