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Titlebook: Intracranial Germ Cell Tumors; Yutaka Sawamura,Hiroki Shirato,Nicolas Tribolet Book 1998 Springer-Verlag/Wien 1998 Nervous System.Tumor.bi

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Prognosis of CNS GCTs,tumor, choriocarcinoma, mature teratoma, immature teratoma, teratoma with malignant transformation, and mixed GCTs (see Chapter IV Pathology). Furthermore, the mixed GCTs include numerous and diverse histological combinations such as an immature teratoma with germinoma, an immature teratoma with emb
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Overview for management,reover, the similarity of the clinical presentations and radiological findings for these tumors makes selection of the management protocol even more complex. The degree to which radiation therapy should be combined with chemotherapy in the treatment of each type of GCTs, therefore, has been debatabl
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Chemotherapy for CNS GCTs,us GCTs). Germinomas are exquisitely radiosensitive; 65% to 95% 5-year survival rates have been reported for patients with germinomas when the treatment is irradiation alone. Non-germinomatous GCTs are less sensitive to irradiation and the 5-year survival rates for patients afflicted with them range
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Radiotherapy for CNS GCTs, determine the radiosensitivity of the tumor without histological confirmation. However, there is no longer any justification for the use of “diagnostic radiotherapy” or “radiation tests” in order to inspect the histologic nature of pineal and neurohypophyseal lesions. Radiotherapy should not be giv
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Adverse effect of therapy and late sequelae in survivors,ormone (GH) deficiency, ii) induction of precocious puberty [1,2,51], iii) effects on growth plate of bone [51], and possibly iv) dysfunction of testis or ovary and thyroid gland when these are irradiated (see the section on Hypothalamic-pituitary Function and Their management). Shalet et al. estima
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