| 书目名称 | Intracellular Traffic and Neurodegenerative Disorders |
| 编辑 | Peter H. St. George-Hyslop,William C. C. Mobley,Yv |
| 视频video | |
| 丛书名称 | Research and Perspectives in Alzheimer‘s Disease |
| 图书封面 |  |
| 描述 | .This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically. Many adult onset neurodegenerative diseases appear to arise from the accumulation of misfolded, neurotoxic peptides. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an important role in the biology of neuronal function and survival, this also addresses how trophic factors maintain cell: cell interactions and how the underlying mechanisms may be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated.. |
| 出版日期 | Book 2009 |
| 关键词 | Alzheimer; Alzheimer‘s disease; Huntingdon‘s disease; amyloid precursor protein; axonal transport; intram |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-540-87941-1 |
| isbn_softcover | 978-3-642-09972-4 |
| isbn_ebook | 978-3-540-87941-1Series ISSN 0945-6066 Series E-ISSN 2196-310X |
| issn_series | 0945-6066 |
| copyright | Springer-Verlag Berlin Heidelberg 2009 |
发表于 2025-3-21 17:37:58
