Titlebook: International Manual of Oncology Practice; (iMOP) - Principles Ramon Andrade de Mello,Álvaro Tavares,Giannis Moun Textbook 20151st edition

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Understanding Cancer Stem Cells Biology to Get Rid of Tumoursriginate differentiated tumour cells responsible for the overall organization and heterogeneity of the tumour tissue. CSC have been identified and isolated from a wide range of human tumours, including solid tumours, and are thought to play a central role in the tumour initiation, progression and me

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Apoptosis to environmental genotoxic compounds) and endogenous sources such as replication fork collapse during regular DNA replication, during normal DNA repair events and immunoglobulin V(D)J gene rearrangement. However the incorrect repair of DNA breaks results in significant genomic instability due to gr

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Tumour Angiogenesisapeutic implications” (N Engl J Med 285:1182–1186, 1971). At the time Folkman proposed three bold postulates: (i) angiogenesis is essential for tumour growth beyond minimal size; (ii) tumours secrete a “tumor angiogenesis factor” that is responsible for inducing angiogenesis; and (iii) anti-angiogen

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Genetic Basis of Metastasisare several characteristics that are common to all cancers such as unrestrained proliferation and evasion of cell death. Another common feature is that of metastasis. Metastasis is “initiated” when primary tumor cells acquire the ability to invade surrounding tissues and eventually develop secondary

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Lung Cancer: Diagnosis and Treatment Approachnic lung disease, race and ethnicity, occupational carcinogen exposure, diet and genetic factors. Until now there have been no effective modalities for the early detection of lung cancer. The National Cancer Institute recently released results from its National Lung Screening Trial (NLST) which show

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Gastric Cancer: Molecular Mechanisms, Diagnosis, and Treatment gastric cancer remains poor, with 5-year relative survival of only 3.9 %. Many risk factors have been identified in relation to gastric cancer, including ., Epstein-Barr virus infection, family history of gastric cancer, and the presence of pathologic changes such as atrophic gastritis, intestinal