Titlebook: Interferons: Mechanisms of Action and Role in Cancer Therapy; Derek Crowther Conference proceedings 1991 Springer-Verlag Berlin Heidelberg

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ochemical mechanisms and theresults of important new clinical studiesusing theinterferons.Reviews include what is presently known aboutthebiosynthesis, physiological role and mechanisms of action oftheinterferons (alpha, beta, gamma). New biochemicalinformation oninterferon-receptor interactions and

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,The Interferons: Their Properties and Clinical Role — An Overview, most vertebrate cells when they are appropriately stimulated. Interferon was originally described as a glycoprotein containing about 150 amino acids. It is now known that several types of interferon exist with differing amino-acid composition and varying amounts of carbohydrate.

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The Role of Interferons in Neuroendocrine Tumours and Aspects of Mechanisms of Action,glycaemic symptoms due to insulin overproduction, and the glucagonoma syndrome due to glucagon production. There also exists a group of tumours, the so-called “non-functioning” tumours, which produce hormones that do not cause any definite clinical syndrome [1].

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Conference proceedings 1991 pathways is provided. The pharmacokineticconsiderations in treating leukemia, lymphoma,myeloma,neuroendocrine tumors and other solid tumors are reviewedwith special emphasis on studies of adjuvant chemotherapy inmalignancies of the immune system.

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signalling pathways is provided. The pharmacokineticconsiderations in treating leukemia, lymphoma,myeloma,neuroendocrine tumors and other solid tumors are reviewedwith special emphasis on studies of adjuvant chemotherapy inmalignancies of the immune system.978-3-642-76789-0978-3-642-76787-6

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The Interferons plus Other Modalities of Cancer Therapy,olume disease state has been achieved by other treatments, is another approach which is proving to be of some value. The aim of this chapter is, therefore, to discuss the available data relating to the use of the IFNs in combination with these other treatment modalities.

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The Role of Interferon in the Management of Low-Grade Lymphoma,ncers, interferon is ineffectual. However, with regard to haematological malignancy, it was subsequently shown to be active in hairy-cell leukaemia [2-5], the myeloproliferative disorders chronic myeloid leukaemia [6,7] and essential thrombocythaemia [8], myeloma [9] and low-grade lymphoma [10–17].

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Interferons: Biosynthesis, Physiological Roles, Mechanisms of Induction and Response, of IFN mediate their effects. For a recent general review of the IFNs, see Pestka et al. [1] and for a comprehensive review of the role of IFN in treating human neoplasia, with several sections of background information, see Strander [2].