| 书目名称 | Interferon: The 50th Anniversary | | 编辑 | Paula M. Pitha | | 视频video | http://file.papertrans.cn/471/470999/470999.mp4 | | 概述 | Includes supplementary material: | | 丛书名称 | Current Topics in Microbiology and Immunology | | 图书封面 |  | | 描述 | .Over the last half of century interferon (IFN), originally discovered as an antiviral protein, has developed from an inhibitor of viral replication to a major force in the antiviral response. Initially studied only by few virologists, IFN was generally considered as a poorly defined protein of limited importance. The development of molecular techniques lead to the identification of a family of IFN genes and has shown an unexpected complexity of type I IFN genes and their expression. Presently, some aspects of the of the pathogen mediated induction of IFN gene expression are understood at molecular level, while others are still at the stage of description. Both Toll like receptors and cytoplasmic RNA helicases were shown to recognize viral nucleic acids and the basis of a distinct recognition of viral nucleic acids from the cellular ones are emerging. Important insights on the virus recognition entity, leading to the expression of interferon and interferon induced genes, have been made in the recent year, which are challenging the accepted concept of the critical role of dsRNA in IFN induction. The availability of genetically modified mice that are lacking either essential componen | | 出版日期 | Book 2007 | | 关键词 | RNA; autoimmune disease; autoimmunity; cell; cytoplasm; diseases; gene; gene expression; immune system; infec | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-540-71329-6 | | isbn_softcover | 978-3-642-09044-8 | | isbn_ebook | 978-3-540-71329-6Series ISSN 0070-217X Series E-ISSN 2196-9965 | | issn_series | 0070-217X | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
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