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Titlebook: Integer Programming and Combinatorial Optimization; 25th International C Jens Vygen,Jarosław Byrka Conference proceedings 2024 The Editor(s

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Rajni Dabas,Naveen Garg,Neelima Guptaong underestimated, and research has been focused mainly on glomerular pathology. Recently, more studies evaluated tubular damage, since it became obvious that tubulointerstitial fibrosis and tubular atrophy show a major correlation with the declined renal function in DN. Hyperglycemia induces tubul
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Jesús A. De Loera,Brittney Marsters,Luze Xu,Shixuan Zhanghe glomerulus, although tubulointerstitial and vascular lesions are also well documented. This chapter focuses on the metabolic abnormalities of proximal tubules in the pathogenesis of DN since diabetes is a metabolic as well as a vascular disease, partly resulting from glucose toxicity. Sirt1 is an
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Omar El Housni,Alfredo Torrico,Ulyssee Hennebelleong underestimated, and research has been focused mainly on glomerular pathology. Recently, more studies evaluated tubular damage, since it became obvious that tubulointerstitial fibrosis and tubular atrophy show a major correlation with the declined renal function in DN. Hyperglycemia induces tubul
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Yuri Faenza,Ayoub Foussoul,Chengyue Hethat genetic factors contribute to their susceptibility. Motivated by these studies, researchers have been working for the past 20 years to identify the causal genes responsible for the development of DN. During this period, advances in genomics and evolving technologies have revolutionized our abil
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Yuri Faenza,Clifford S. Stein,Jia Wanl innovations that attempt to mimic pancreatic endocrine function. The normal pancreas secretes insulin constantly at a rate based on the metabolic needs of the individual. The basal rate of insulin secretion is relatively constant and comprises about one-half the total 24-hour insulin output, or ab
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Ayoub Foussoul,Vineet Goyal,Amit Kumarralds the last act in the course of a disease that will increasingly become the dominant preoccupation in the patient‘s shortened life. For most type II diabetics, the beginning of clinical renal insufficiency is but a phase in a continuous deterioration that affects the integrity ofjob, marriage, a
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Anupam Gupta,Jinqiao Hu,Gregory Kehne,Roie Levinochemical binding between cells through multiprotein complexes that functionally mediate adhesion. Importantly, the direct connection of physical properties and intercellular signaling is of great importance to certain pathologies including diabetes. Atomic force microscopy (AFM) single-cell force s
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