Titlebook: Insulin Resistance; Childhood Precursors Philip S. Zeitler,Kristen J. Nadeau Book 2020Latest edition Springer Nature Switzerland AG 2020 Ad

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Genome

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Adiposity Is the Enemy: Body Composition and Insulin Sensitivitye the advent of advanced imaging techniques in the 1980s and 1990s, it has become apparent that insulin resistance is actually associated with the increase in body fatness that occurs during aging, rather than aging per se. In addition, these imaging techniques have fueled the debate about which reg

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Ectopic Fat and Insulin Resistance in Youth distribution, instead of total adiposity, is the main predictor of metabolic derangement in adults and children. Indeed, lipid accumulation in insulin-sensitive organs, such as liver and skeletal muscle, might impair insulin action leading to insulin resistance. In this chapter, we review the scien

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Offbeat

Insulin Resistance and Cardiovascular Diseasesity increase the risk for cardiovascular (CV) events in adults. There are numerous proposed mechanisms to explain the association between IR and early CV disease. These include actions at the level of the vascular endothelium, including alterations in the normal vasodilatory nitric oxide response,

Expediency

The Liver and Insulin Resistance: The Important Convergence of Endocrinology and Hepatologyibes the association between cirrhosis and development of diabetes, and more recently to the term “diabetic fatty liver,” which antedated the now more common terms “nonalcoholic steatohepatitis” (NASH) and “nonalcoholic fatty liver disease” (NAFLD). The ever-rising prevalence of obesity has brought

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通知

Intrauterine Growth Restriction and Insulin Resistanceted by intrauterine growth restriction (IUGR), but the molecular mechanisms underlying this phenomenon have not been fully defined. In this chapter, we highlight population-based studies from which the link between IUGR and the development of insulin resistance in childhood and adulthood has been de

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