Titlebook: Insulin & Related Proteins — Structure to Function and Pharmacology; Markus Leyck Dieken,Matthias Federwisch,Pierre Mey Book 2002 Springer

Recess

T-R Transition,n these structural states are related by dynamic equilibria, the transitions between them being ligand controlled. The history of the detection and investigation of the solution structural transitions is outlined and a few recent results are presented. Meanwhile insulin has been established as an ou

任命

Comparison of Conformational Transitions in Proteins,often associated with functional aspects. The investigation of large transitions using experimental methods usually exhibits macroscopic properties. In insulin the . transition has been investigated by simulation techniques. A method named Targeted Molecular Dynamics’ has been developed in this cont

GRILL

Activities of Insulin Analogues at Position A8 are Uncorrelated with Thermodynamic Stability,on the surface of insulin stabilize the N-terminal . of the A chain, a key element of hormone-receptor recognition. Does enhanced stability necessarily imply enhanced activity? Here, we test a proposed correlation between the hormone’s thermodynamic stability and biological activity by comparison of

指派

Relationships between the Structure of Insulin and its Physiological Effects,tic portal vein, which flows directly to the liver, it acts initially to modulate hepatic glucose output, an effect primarily responsible for glucose homeostasis. Only 50% of secreted insulin passes from the liver to the other tissues where it has a role in controlling lipolysis and glucose uptake p

originality

Structure-Function Relationships of Insulin and Insulin-Like Growth factor-I Receptor Binding,ide family, their structure-function relationships and mapping of the binding sites on the ligands and receptors by site-directed mutagenesis. We discuss a plausible bivalent crosslinking binding model that explains the complex binding properties of insulin and the IGFs.

fabricate

remission

毕业典礼

Identification of Susceptibility Loci for Obesity, Insulin Resistance, and Hyperglycemia in a Backcd Obese (NZO) mice with the lean SJL strain was established in order to locate genes responsible for obesity, insulin resistance, and type 2 diabetes-like hyperglycemia. In male NZOxFl backcross mice, a major susceptibility locus for the development of severe hyperglycemia (.) was identified on chro

Ablation

Activation Mechanism of Fibroblast Growth Factor Receptor Tyrosine Kinase Revealed by Crystal Strucroblast growth factor with its receptor tyrosine kinase (FGFR) and heparin-like heparan sulphate proteoglycan in a specific complex on the cell surface is essential for signal transduction. Here we report the crystal structure of the FGFR2 ectodomain in a dimeric form, induced by simultaneous bindin

stressors

IL-6 Type Cytokine Receptor Complexes, not been found in other proteins. The interleukin-6 (IL-6) type cytokine family comprises six members. IL-6 type cytokines interact with three receptor subunits instead of the usual two subunits. A tetramer would be the simplest model to describe such a receptor complex, but present orthodoxy descr