Titlebook: Inositol and Phosphoinositides; Metabolism and Regul John E. Bleasdale,Joseph Eichberg,George Hauser Book 1985 The Humana Press Inc. 1985 A

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The Mechanism of Enzymatic Isomerization of Glucose 6-Phosphate to L-,-Inositol 1-phosphatem glucose 6-phosphate. Since inosose-2 1-phosphate is sufficiently long-lived to be trapped by borotritide reduction, its reduction by putative NADH in the enzymatic reaction must be the rate limiting step, and thus the site of hydrogen isotope effects observed previously.

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Nutritional Regulation of the Composition, Metabolism, and Function of Cellular Phosphatidylinositolroduce a reduction in phosphatidylinositol levels and a marked accumulation of hepatic triglyceride in several animal species. The consumption of certain types of dietary fatty acids (., fish oils containing eicosapentaenoic acid) produces a lowering of the arachidonoyl phosphatidylinositol in human

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Detection of Receptor-Linked Phosphoinositide Metabolism in Brain of Lithium-Treated Rats reversed by atropine, we believe that the seizure activity itself contributes to the increase in IP observed. Nicotine, when administered subcutaneously to the lithium-treated rat, suppresses IP levels, while the two nicotinic cholinergic ganglionic blockers mecamylamine and pempidine give rise to

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The Enzymology of Phosphoinositide Catabolism, with Particular Reference to Phosphatidyl-Inositol 4,-bilayer” configuration is too simplistic to explain the enzyme’s preferences. Furthermore, it may be that the head-groups of phospholipids adjacent to the PIP. substrate can also directly affect the activity. We suggest that . PIP. phosphodiesterase is not controlled by calcium, nor by enzyme prote

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Subcellular Sites of Polyphosphoinositide Metabolism in Rat Liverand PIP. in subcellular organelles were also determined after fractionation of isolated rat hepatocytes incubated with .P.. [.P]PIP. synthesis is confined almost exclusively to the plasma membrane, while [.P]PIP is found in other subcellular fractions as well. These studies suggest that the primary

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The , Phospholipid Synthesis Effect: Occurrence, Characteristics, Underlying Mechanisms and Functiontors, transporters and enzymes. The . phospholipid effect may be important in the following: (a) regulation of steroidogeness by ACTH, luteinizing hormone, angiotensin and K in adrenal and ovarian tissues; (b) insulin action on pyruvate dehydrogenase and glucose and lipid metabolism in adipose tissu

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Hydrolysis of Phosphatidylinositol 4-phosphate and Phosphatidylinositol(4,5)-Bisphosphate by Specifitwo activities was observed in other mammalian erythrocytes. Homogenates of various rat tissues also exhibit cation-independent Ptdlns4P phosphatase activity which, except for brain, exceeds the .-dependent Ptdlns(4,5)P. phosphatase activity.