Titlebook: Innovative Medicine; Basic Research and D Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto Conference proceedings‘‘‘‘‘‘‘‘ 2015 The Editor(s) (if

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Roles of E-cadherin in Hepatocarcinogenesisherin in liver cancer development has not been elucidated. Thus, we generated liver-specific E-cadherin (.) knockout mice (..) by crossing .. mice with . transgenic mice. Interestingly, .. mice developed spontaneous inflammation in the portal areas, and then developed periductal onion skin–like fibr

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The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumorsto tumorigenesis. The study of mice bearing systemic or tissue-specific mutations of Hippo elements has driven huge progress in understanding this pathway’s role in normal physiology and disease. Here, we summarize how disruption of Hippo signaling relates to cancer, and we highlight the importance

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Inhibitory Immunoreceptors on Mast Cells in Allergy and Inflammationvely. Inhibitory receptors are characterized by the immunoreceptor tyrosine-based inhibition motif (ITIM) in their cytoplasmic domains and play an important role in immune regulation by both lymphoid and myeloid cells. Mast cells express the high-affinity receptor for IgE (FcεRI) and toll-like recep

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Doxycycline-Inducible Autoimmune Blistering Skin Disease Model7) and BP230, with autoimmunity to COL17 being mainly involved in the development of the disease. BP most commonly affects the elderly, and systemic corticosteroids are widely used to treat blisters on the entire body. Therefore, severe cases are sometimes fatal. Toward developing innovative, diseas

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